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新鲜出炉|免费下载类风湿关节炎发病机制信号通路图

2022/8/9 15:35:08      点击:

类风湿关节炎(Rheumatoid Arthritis,RA)是一种全身性、慢性炎症性疾病。虽然RA的确切原因尚未明确,但遗传和环境因素都与RA的易感性改变有关。类风湿关节炎会反复持续激活先天和适应性免疫系统,随着时间的推移,会导致免疫耐受失败、自身抗体产生和炎症细胞因子过量产生。这反过来又会导致类风湿关节炎症,最终导致永久性的、致残的软骨和骨骼损伤。类风湿性关节炎患者也可能出现肺部和心脏的全身性炎症。

类风湿关节炎的发病机制是一个跨越数十年的复杂过程,涉及多种细胞类型和信号通路。CST信号通路图展示了参与类风湿性关节炎发病机制的不同细胞类型如何相互作用,并指出 RA 诱导分子和 RA 抑制分子,以及潜在的治疗机制,包括能够观察类风湿性关节炎发病机制的细胞类型、信号通路和分子的关键 CST 产品列表。

货号

产品名称

应用

反应性

67824

ASC/TMS1 (D2W8U) Rabbit mAb (Mouse Specific)

W IP IHC-P IF-F IF-IC F

M

17507

ASC/TMS1 (D2W8U) Rabbit mAb (Mouse Specific) (Alexa Fluor® 488 Conjugate)

IF-IC F

M

2873

ATM (D2E2) Rabbit mAb

W

H M

98033

Caspase-1 (E4R8K) Rabbit mAb

W IHC-P

H

89332

Cleaved Caspase-1 (Asp296) (E2G2I) Rabbit mAb

W IP

M (R)

4199

Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb

W IP

H (Mk)

78588

CD3ε (E4T1B) XP® Rabbit mAb

W IP IHC-Bond IHC-P IF-F

M

85061

CD3ε (D7A6E™) XP® Rabbit mAb

W IP IHC-Bond IHC-P

H Mk

26582

CD3 (17A2) Rat mAb (redFluor™ 710 Conjugate)

IF-F F

M

48274

CD4 (EP204) Rabbit mAb

IHC-Bond IHC-P

H

25229

CD4 (D7D2Z) Rabbit mAb

W IHC-Bond IHC-P

M R

96127

CD4 (RM4-5) Rat mAb (FITC Conjugate)

IF-F F

M

98941

CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific)

W IHC-Bond IHC-P

M

85336

CD8α (D8A8Y) Rabbit mAb

W IP IHC-P F

H

64786

CD8α (2.43) Rat mAb (APC Conjugate)

IF-F F

M

86165

CD40 (E2Z7J) Rabbit mAb

W IP IHC-Bond IHC-P

M

40868

CD40 (D8W3N) Rabbit mAb

W IHC-Bond IHC-P

H

15094

CD40 Ligand (D5J9Y) Rabbit mAb

W IP IHC-P

H

13917

CD45 (Intracellular Domain) (D9M8I) XP® Rabbit mAb

W IP IHC-P IF-IC F

H Mk

98819

CD45 (D3F8Q) Rabbit mAb (BSA and Azide Free)

IHC-Bond IHC-P IF-F IF-IC

M

19581

CD45 (D3F8Q) Rabbit mAb (Alexa Fluor® 555 Conjugate)

IF-F IF-IC

M

72031

CD57 (HNK-1) Mouse mAb

IHC-Bond IHC-P IF-IC

H

72031

CD68 (D4B9C) XP® Rabbit mAb

IHC-P IF-IC F

H

97778

CD68 (E3O7V) Rabbit mAb

W IHC-Bond IHC-P IF-F IF-IC F

M

51644

CD68 (E3O7V) Rabbit mAb (Alexa Fluor® 488 Conjugate)

IF-F IF-IC F

M

24595

CD206/MRC1 (E6T5J) XP® Rabbit mAb

W IP IHC-Bond IHC-P IF-F

H M R Mk

59414

CD206/MRC1 (E6T5J) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate)

IF-F

H M R

10137

Cleaved Gasdermin D (Asp276) (E3E3P) Rabbit mAb

W

M

36425

Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb

W IP IHC-P

H

12311

DNA-PKcs (3H6) Mouse mAb

W IHC-P IF-IC

H Mk

70076

F4/80 (D2S9R) XP® Rabbit mAb

W IP IHC-P

M

66562

FAP (E1V9V) Rabbit mAb

W IP IF-IC

H

39754

Gasdermin D (E9S1X) Rabbit mAb

W IP

H M R Hm

4814

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen)

W IP IHC-P IF-IC F

H M R Mk B Pg

7523

IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (PE Conjugate)

F

H M R Mk B Pg

12703

IL-1β (D3U3E) Rabbit mAb

W IF-IC F

H

12242

IL-1β (3A6) Mouse mAb

W IHC-P

H M

12912

IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific)

W IP IF-IC F

M

13797

IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific) (PE Conjugate)

F

M

18935

IL-6Rα/CD126 (E5B3P) Rabbit mAb

W IP IF-IC F

H

3230

Jak2 (D2E12) XP® Rabbit mAb

W IP IHC-P

H M R (Hm) (Mk) (C) (X) (B) (Dg) (Pg) (Hr)

3776

Phospho-Jak2 (Tyr1007/1008) (C80C3) Rabbit mAb

W

H M R (Mk) (B)

63125

FastScan™ Phospho-Jak2 (Tyr1007/1008) ELISA Kit

ELISA

H M

68258

MHC Class II (LGII-612.14) Mouse mAb

W IP IHC-Bond IHC-P F

H

4847

Mre11 (31H4) Rabbit mAb

W IP IHC-P

H

4895

Mre11 Antibody

W IP IHC-P

H M R Mk

8242

NF-κB p65 (D14E12) XP® Rabbit mAb

W IP IHC-P IF-IC F ChIP ChIP-seq C&R

H M R Hm Mk Dg

3033

Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb

W IP IF-IC F

H M R Hm Mk Pg (Dg)

4887

Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb (Alexa Fluor® 647 Conjugate)

F

H M R Hm Mk Pg (Dg)

26981

Podoplanin (LpMab-12) Mouse mAb

IHC-P F

H

9139

Stat3 (124H6) Mouse mAb

W IP IHC-P IF-IC F ChIP

H M R Mk

9145

Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb

W IP IHC-Bond IHC-P IF-IC F ChIP ChIP-seq

H M R Mk (Hm) (B) (Pg) (Hr)

8119

Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (PE Conjugate)

F

H M R Mk (Hm) (B) (Pg) (Hr)

16242

FastScan™ Phospho-Stat3 (Ser727) ELISA Kit

ELISA

H M R Mk

11948

TNF-α (D2D4) XP® Rabbit mAb (Mouse Specific)

W IP IF-IC F

M

87509

TNF-α (D2D4) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate)

F

M

8184

TNF-α (D1G2) Rabbit mAb (IF/Flow Preferred)

W IP IF-IC F

H

96865

TNF-α (D1G2) Rabbit mAb (PE-Cy7® Conjugate)

F

H

13801

Thy1/CD90 (D3V8A) Rabbit mAb

W IHC-P

H M R


类风湿性关节炎发病机制和相关抗体信号通路图,可用于研究与自身免疫性疾病相关靶点。


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